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Regimen
to promote neuroprotection and encourage nerve
repair (plus
a compendium of resources and promising adjunctive therapeutic agents for
Multiple Sclerosis and other neurological diseases &
disorders) Dr.
Anthony G. Payne Steenblock
Research Institute (949) 248-7034 E-mail:
DrAGPayne@yahoo.com Suggested
regimen to help quell inflammation and promote nerve repair in various
neurodegenerative and neuroinflammatory diseases
and disorders Diet:
Paleolithic (“Stone Age”).
30% or more protein (2:1 ratio of omega-3 to omega-6 fatty acid containing
fish, game meat, etc., 1:1 Magnesium to Calcium intake, low sodium-high
potassium) 70% complex carbohydrates (Fruits and vegetables).
No grains, cereals or
bovine milk. (Helpful dietary chart can be found
below) Use
of curry and Tumeric powder in foods is
encouraged. 20
minutes before or 1 hour after meals: 800
mgs. to 1 gram: N-acetylcysteine 1
gram of Acetyl-L-carnitine 500
mgs. to 1 gram: Taurine With
meals: 500
mgs. to 1.0-1.5 grams time-released Niacinamide 50
mgs. Thiamine (B1) 50-100
mgs. R-Lipoic Acid 50
mgs. Non-toxic NDGA T4
(Thyroid) – Check
with primary care physician regarding advisability of using this (MD or DO
must monitor T4 hormone level regularly). Abstract concerning rationale
for inclusion in references section.
May
be of merit - Discuss with primary healthcare provider Velvet
Deer Antler extract
(Spray or tablets). Follow product label
recommendations. Cinnamon
Extract Capsules
(Counters glutamate neurotoxicity). Follow
product manufacturer recommendations. Abstract in reference
section. Drink magnesium rich “hard”
water as often as possible: http://www.mgwater.com/list5.shtml
. Also make green tea
using this type of water (See below) Make and drink organic Japanese green tea 2-3 times daily http://www.o-cha.com/green-tea/Organic-Matcha-P300-Kaoru-Supreme-pr-16138.html -. This is one of the best,
“Kaoru Supreme” Make using a magnesium
rich water (See above for one
source). NOTE:
Author has no financial or other interest in this firm or any
commercial source listed in this free access
regimen. Glycerophosphocholine (GPC) – 1 or 2 capsules one (1) hour
before or 2 hours following meals. Phosphatidylserine (PS) – 1 softgel 3 x daily or more often. Luteolin: The scientific evidence for the
benefits of luteolin for various neurologic challenges is beginning to accrue. One
luteolin-rich source is a product called ”Lutimax” -- http://www.lutimax.com/radicals.html
Rooibos
Tea (Rich in luteolin): http://www.dragonwater.com/search.tf/tea/rooibos_tea/?z=go_rooibos_tea&gclid=CKq9g-rR6IMCFQMZIgodqzqpLw - Organic Rooibos Tea L-Theanine Take 1 capsule with or after each
meal and snack and then 2 capsules 30 minutes before retiring at night
(Theanine appears to contribute to mood
modulation and relaxation-promotion via its ability to increase
GABA and dopamine) DIETARY
GUIDELINES -- PALEODIET
Resources,
References, Supporting Material http://www.stemcelltherapies.org/ms.htm - This link is to a very
comprehensive article on alternative approaches to treating MS (by Dr.
David A. Steenblock, Medical Director & CEO,
Steenblock Research Institute, Research & Development
Laboratory, 1064 Calle Negocio #B, http://www.strokedoctor.com/ - Dr.
Steenblock’s medical practice website - devoted
to brain repair and rehabilitation. Many good research papers and such
posted on this website. http://author.emedicine.com/NEURO/topic286.htm
- Organophosphates, general. http://www.safe2use.com/ca-ipm/00-11-12.htm
- The Chronic and Delayed Effects of Organophosphate (OP)
Poisoning http://www.lef.org/protocols/prtcl-156.shtml
- Heavy metals
toxicity http://www.webnat.com/ - Neurodegenerative diseases and
conditions: Causes, natural and other treatments, et cetera Diet,
supplements, abstracts, etc. Tumeric
(Curcumin) Curcumin
(Diferuloylmethane) is a compound found in the
Indian curry spice, tumeric.
It
has been discovered that people in Curry spice may fight multiple
sclerosis
Discovery
of natural products from Curcuma longa that
protect cells from beta-amyloid insult: a drug
discovery effort against Alzheimer's disease.
The
curry spice curcumin reduces oxidative damage
and amyloid pathology in an Alzheimer transgenic
mouse.
Curcumin
inhibits experimental allergic encephalomyelitis by blocking IL-12
signaling through Janus kinase-STAT pathway in T
lymphocytes. According
to researcher Dr. Chandramohan Natarajan of Vanderbilt University in Nashville,
Tennessee, rats with an MS-like illness showed little or no signs of
disease symptoms after being injected with curcumin, while animals without the treatment went on
to severe paralysis. "We
got a very good inhibition of the disease by treating with curcumin," Natarajan told
Reuters Health. He presented the findings here Tuesday at the annual
Experimental Biology 2002 conference. No
one knows what causes multiple sclerosis, in which the body's immune
system attacks the protective myelin sheath surrounding nerve fibers in
the brain and spine. Symptoms of multiple sclerosis include muscle
weakness and stiffness, balance and coordination problems, numbness and
vision disturbances. Interest
in the potential neuroprotective properties of
curcumin rose after studies found very low
levels of neurological diseases such as Alzheimer's in elderly Indian
populations. Added to this were studies confirming curcumin as a potent anti-inflammatory agent,
effective in wound healing. And just last fall, researchers at the
In
their 30-day study, Natarajan and co-researcher
Dr. John Bright gave injections of 50- and 100-microgram doses of curcumin, three times per week, to a group of mice
bred to develop a disease called experimental autoimmune encephalomyelitis
(EAE)--an autoimmune condition used by researchers as a model for multiple
sclerosis because it also results in the slow erosion of myelin. They then
watched the rats for signs of MS-like neurological impairment.
By
day 15, rats who had not received curcumin
developed EAE to such an extent that they displayed complete paralysis of
both hind limbs, according to Natarajan.
In
contrast, rats given the 50-microgram dose of the curry compound showed
only minor symptoms, such as a temporarily stiff tail. And rats given the
100-microgram dose appeared completely unimpaired throughout the 30 days
of the study. The
results didn't really surprise Natarajan. "In
Asian countries, such as India, China, who are eating more spicy foods,
more yellow compounds like curcumin...there are
only very, very rare reports of MS," he pointed out. He said the doses the
rats received were roughly equivalent in human terms to those found in a
typical Indian diet. Just
how curcumin might work to thwart the
progression of demyelinization remains unclear.
But the Natarajan
stressed that "we have to do a lot of work on this," including examining
other potential mechanisms by which curcumin
slows EAE and, potentially, MS. The
work remains preliminary, and MS patients should follow their doctor's
advice when it comes to treating the disease. Still, Natarajan said adding a little curry to the diet
couldn't hurt. "I think using this spice in their food could be of help,"
he said. http://www.iherb.com/tumeric.html Blue
Wavelength light exposure may ameliorate MS Animal
Model of Multiple Sclerosis: ・To
help in research of multiple sclerosis (MS) researchers utilize an animal
model, experimental allergic encephalitis (EAE). EAE is an acute
autoimmune demyelination disease, that matches the
symptomatology
of MS. Guinea pigs with EAE are reported to have a reduction of
serotonin within the central nervous system (CNS), when compared to
control subjects. The reduction of serotonin within the CNS leads to an
effect on CNS serotonin transmissions in EAE, either at the level of
serotonin receptor itself, or at the level of serotonin transmitting
neurons (Scott, Cashman, and Spitler,
1982-83). The symptoms of EAE are due to the inhibition of
serotonin transmission.
http://www.cwu.edu/~chem/courses/chem388488f00/kusche/multiple/animal.htm -------------------------------------------------------------------------------------------------------- Scientific
Breakthrough Several
very recent studies, most notably research from a team headed by Dr.
George Brainard at Thomas Jefferson Medical
College in Philadelphia, have identified the specific wavelengths of
blue light, 446-477 nm that are crucial in suppressing melatonin
production in humans. 1 2 3 4 As Dr. Brainard notes, "This discovery will have an immediate
impact on the therapeutic use of light for treating winter depression and
circadian disorders." Melatonin, the neurotransmitter that helps us
sleep deeply through the night, is produced from serotonin.
Suppressing melatonin production raises the levels of serotonin in our
brains. This is the key goal of therapeutic bright light
treatment. This neurological pathway entrains our circadian rhythm
to be awake during the day and sleep deeply at night. Four
cells in the human retina capture light and form the visual system.
One type, rod cells, regulates night vision. The other three types,
called cone cells, control color vision. It's known that exposure to
light at night can disrupt the body's production of melatonin, which is
produced by the pineal gland in the brain and plays a vital role in
resetting the body's daily biological clock. Dr.
Brainard and his group showed that the combined
three-cone system didn't control the biological effects of light, at least
not for melatonin regulation. But subsequent work led to the
surprising discovery that a novel receptor was responsible for the
effect. The
study looked at the effects of nine different wavelengths of light, from
indigo to orange, on 72 healthy volunteers.
Subjects were brought into the laboratory at midnight, when melatonin is
highest. The subjects' pupils were dilated and then they were
blindfolded for two hours. Blood samples were drawn. Next,
each person was exposed to a specific dose of photons of one light for 90
minutes, and then another blood sample was drawn. Wavelengths of
blue light had the highest potency in causing changes in melatonin
levels, he explains. This
new research indicates that there is an as yet unidentified photopigment; most sensitive at theses wavelengths of
blue light that controls theses neurological reactions to light. As
another researcher notes, this 'provides the first direct evidence of a
non-rod, non-cone photoreceptive system in humans' - one that is activated
by blue light between 420-480 nm. 2 We
are pleased to announce that this research has been incorporated into the
BlueStarTM Light Boxes. The 10 000 lux, BlueStarTM double tubes
have one side that's bright blue (446-477 nm) and one side that's bright
white 85 CRI, 5000K. Clinical use shows that the BlueStarTM Light raises serotonin in 15-30 minutes,
instead of the 1-2 hours necessary with bright hi lux light 1
Brainard
G, Hanifin J, Gresson
J, et al (2001) Action Spectrum for
Melatonin Regulation in Humans: Evidence for a Novel Circadian
Photoreceptor. Neurosci (16):
6405-6412 2
Physiology
and Biophysics of
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